Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Inhibitory Effect of Cycloartenol Ferulate, a Component of Rice Bran, on Tumor Promotion in Two-Stage Carcinogenesis in Mouse Skin
Ken YASUKAWAToshihiro AKIHISAYumiko KIMURAToshitake TAMURAMichio TAKIDO
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1998 Volume 21 Issue 10 Pages 1072-1076

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Abstract

Inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice was observed in the methanol extract of rice bran and γ-oryzanol. The active components of rice bran, sitosterol ferulate, 24-methylcholesterol ferulate, cycloartenol ferulate and 24-methylenecycloartanol ferulate inhibited markedly the TPA-induced inflammation in mice. The 50% inhibitory does of these compounds for TPA-induced inflammation was 0.2-0.3 mg/ear. Furthermore, cycloartenol ferulate markedly inhibited the tumor-promoting effect of TPA in 7, 12-dimethylbenz[a]anthracene-initiated mice.

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© The Pharmaceutical Society of Japan
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