Thermodynamic Studies of the Charge-Transfer Interactions of Chloranilic Acid with Moclobemide and Promethazine Hydrochloride

Abstract

Spectrophotometric absorption studies geve evidence for the formation of strongly bonded charge-transfer complexes between moclobemide and promethazine hydrochloride with chloranilic acid in non-aqueous media comprising chloroform and 1, 4-dioxane. The transitions involved were detected at wavelengths longer than those of the single pure substances in the visible region. Equilibrium constants from the Scott equation could be measured together with other thermodynamic parameters and molar absorptivities at different temperatures. Theoretical arguments are presented as to the spontaneity of these interactions.