NOVEL THIAZOLIDINEDIONE DERIVATIVES WITH RETINOID SYNERGISTIC ACTIVITY

Masayuki RBISAWA; Emiko KAWACHI; Hiroshi FUKASAWA; Yuichi HASHIMOTO; Akiko ITAI; Koichi SHUDO; Hiroyuki KAGECHIKA

doi:10.1248/bpb.21.547

Masayuki RBISAWA, Emiko KAWACHI, Hiroshi FUKASAWA, Yuichi HASHIMOTO, Akiko ITAI, Koichi SHUDO, Hiroyuki KAGECHIKA

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Keywords: thiazolidinedione, retinoid, cell differentiation, synergist

JOURNAL FREE ACCESS

1998 Volume 21 Issue 5 Pages 547-549

DOI https://doi.org/10.1248/bpb.21.547

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Abstract

Several arylmethylidene thiaxolidinediones were synthesized and their retinoidal activities were examined. TZ181 (7a), having a benzanilide skeleton, exhibited differentiation-inducing activity in HL-60 cell assay, while TZ191 (7b), the N-methylated analog of TZ181 (7a), TZ245 (9) and TZ335 (10) acted as retinoid synergists like the RXR-selective ligand, LGD1069 (5).

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