Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Basic Studies on N"-Ursodeoxycholyldiethylenetriamine-N, N, N'-triacetic Acid for the Dissolution of Calcified Gallstones
Makoto TAKAHASHIToshio KONISHIYorinobu MAEDAMasataka FUKUZAWAToshihiro NISHIDAToshihide OHYAKouji KATAYAMANorihiko KAKEHIHiroo SAKAKURAAtsushi TAKAGIMinoru MAEDAHirobumi OHAMA
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1998 Volume 21 Issue 6 Pages 551-557

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Abstract

A novel calcium-chelating agent, N"-ursodeoxycholyldiethylenetriamine-N, N, N'-triacetic acid (UDCA-DTTA), was synthesized to study its ability to dissolve calcified gallstones. The chelating activity of the compound was demonstrated by dissolving calcium carbonate in vitro at a high dissolution rate. In the presence of the agent, sliced human gallstone with a composition of more than 50% calcium bilirubinate was thoroughly dissolved, indicating that calcium bilirubinate was dissolved from the gallstone. The ability to dissolve calcium was comparable to that of EDTA. However, the laminar structure of the sliced gallstone did not disappear in the presence of EDTA, whereas the structure disappeared in the presence of UDCA-DTTA. All these results indicate that UDCA-DTTA is an interesting compound as a parent substance for developing a prodrug for an oral or intravenous agent to dissolve calcium-containing gallstones.

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© The Pharmaceutical Society of Japan
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