Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Enhancement of the DNA Damaging Activity of N-Nitrosodimethylamine by Di-(2-ethylhexyl)phthalate in Somatic Cells in Vivo of Drosophila melanogaster
Kazuaki KAWAI
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1998 Volume 21 Issue 6 Pages 579-582

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Abstract

The co-genotoxic effect of di-(2-ethylhexyl)phthalate (DEHP) was studied in an in vivo Drosophila genotoxicity test. DEHP is categorized as a non-genotoxic carcinogen. In this study, DEHP also did not show genotoxicity in Drosophila. When larvae were simultaneously treated with DEHP and N-nitrosodimethylamine (NDMA), the DNA damaging activity of NDMA was increased in the Drosophila DNA repair test. Furthermore, DNA double strand breaks were increased by the same treatment of Drosophila. These results suggest that DNA double strand breaks cause the co-genotoxic effect of DEHP in Drosophila.

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© The Pharmaceutical Society of Japan
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