Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Inhibitory Effects of 5-S-GAD on Phosphorylation of V-SRC and BCR-ABL Tyrosine Kinase
Jae Yoon LEENHo Yong PARKHidesuke FUKAZAWAYoshimasa UEHARAShunji NATORI
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1998 Volume 21 Issue 7 Pages 784-785

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Abstract

We examined the inhibitory effects of N-β-alanyl-5-S-glutathionyl-3, 4-dihydroxyphenylalanine (5-S-GAD), a novel antibacterial substance from the immunized adult Sarcophaga peregrina (flesh fly), on protein phosphorylation using immune complexes of protein tyrosine kinases (PTKs) with anti-PTKs monoclonal antibody. We found that 5-S-GAD directly inhibited not only tyrosine phosphorylation of PTK p60v-src, but also tyrosine phosphorylation of PTK p210BCR-ABL. The inhibitory potency of 5-S-GAD was comparable to that of radicicol and herbimycin A of PTK inhibitor.

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© The Pharmaceutical Society of Japan
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