Inhibition of DNA Topoisomerases by Nidulalin A Derivatives

Seiichi SATO; Yumiko FUKUDA; Ryusuke NAKAGAWA; Takashi TSUJI; Ken UMEMURA; Toshiro ANDOH

doi:10.1248/bpb.23.511

Seiichi SATO, Yumiko FUKUDA, Ryusuke NAKAGAWA, Takashi TSUJI, Ken UMEMURA, Toshiro ANDOH

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Keywords: topoisomerase inhibitor, nidulalin A, F390B, F390C, dihydroxanthone

JOURNAL FREE ACCESS

2000 Volume 23 Issue 4 Pages 511-512

DOI https://doi.org/10.1248/bpb.23.511

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Abstract

Three cytotoxic dihydroxanthone derivatives, nidulalin A(1), F380B(2), and F390C(3) were evaluated for inhibitory activity against DNA topoisomerases. Compounds 1 and 2 inhibited DNA topoisomerase II with IC₅₀ values of 2.2 μM and 16 μM, and 3 inhibited DNA topoisomerase I with an IC₅₀ value of 5.9 μM.

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