Evaluation of Immunotoxic Effects of Arsenic and Other Trace Elements on Human Peripheral Blood Monocytes

抄録

In this study, we examined whether arsenic has any toxicological effects on the differentiation of human peripheral blood monocytes into macrophages by macrophage colony stimulating factor (M-CSF) in vitro compared with that of other trace elements (metallic compounds), and found that trivalent inorganic arsenite sensitively inhibited the M-CSF-induced in vitro maturation of monocytes into macrophages at very low concentrations, nM levels, although other metallic compounds, including chromium, selenium, cadmium, mercury, zinc, nickel, copper, cobalt, manganese and other human pentavalent arsenic metabolites, such as inorganic arsenate, monomethylarsonic acid and dimethylarsinic acid showed cytolethality in monocytes at μ-mM levels [1]. This work may have implications in arsenic-induced chronic inflammatory poisoning in humans.