BioScience Trends
Online ISSN : 1881-7823
Print ISSN : 1881-7815
ISSN-L : 1881-7815
Werner syndrome: A changing pattern of clinical manifestations in Japan (1917~2008)
Makoto GotoYuichi IshikawaMasanobu SugimotoYasuhiro Furuichi
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2013 Volume 7 Issue 1 Pages 13-22


As ~75% of the Werner syndrome (WS) patients recognized between 1904 and 2008 all over the world are of Japanese origin, the most case reports and clinical studies on WS has been published in Japanese journals. Thus, the detailed English-written clinical review on the recent WS case reports has been warranted. Although WS has been characterized by a variety of clinical manifestations mimicking premature aging, the recent longevity and delayed age-associated manifestations observed both from Japanese WS and general population may suggest a common environmental effect on some gene(s) other than WRN and may give us a newer pathophysiological look at WS and also natural aging through the molecular dysfunction of WRN.

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© 2013 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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