ALVEOLAR BONE RESORPTION AFTER CALCIUM DEFICIENCY IN RATS
1973 年 20 巻 1 号 p. 131-144
詳細
1973 年 20 巻 1 号 p. 131-144
The purpose of this experiment was to produce a progressive alveolar bone resorption due to calcium deficient diet and to investigate the subsequent morphological changes of the bone cells. One hundred and twenty-seven Wistar rats aged 35 clays were maintained for 8 weeks on a diet containing either 0.6106% calcium (control group) or 0.0098% calcium (experimental group), both diets being the same in phosphorus content (0.3867%) with adequate vitamin D. The animals of both groups were sacrificed at intervals of two weeks each. Ten animals of the experimental group were replaced with the control diet at the sixth week to see the curative effect on alveolar bone resorption. Serum calcium level in the experimental group was slightly but significantly lower than that of the control. Serum phosphorus level was not different from that of the control group. Severe alveolar bone resorption accompanied with both the indentation from endosteal surfaces and osteocytic osteolysis from the inner site of bone was ascertained by microradiographic examinations. Histological findings of decalcified sections suggested that a number of hypertrophied endosteal cells, not osteoclasts, were attaching to the indentations. These hypertrophied cells, however, were hardly found in the recovered animals. The relation between these phenomena and parathyroid function was discussed.
