ヒト皮膚表面より放出されるアセトンガス量と血中β -ヒドロキシ酪酸濃度との相関

抄録

Since both acetone and β-hydroxybutyrate are metabolized compounds from acetoacetate, the relationship between the concentrations of acetone and β-hydroxybutyrate in gases released from human skin and blood, respectively, were studied. For collecting gases released from human skin, a home-made collector was used. The collector was a bag-type (inner volume, 70 ml), which was made with sheets of perfluoro (ethylene/propylene). After a finger was pushed into the collector at the center of a shield film made by PARAFILM^®, its state was maintained for a period of 3 minutes for collecting human emanated gases from the inserted finger. Then, the acetone concentration in the collector was estimated by gas chromatography. We found a good relationship between them. Its correlation factor was 0.88 (p <0.01). The concentration of acetone can be used as an alternative marker for β-hydroxybutyrate in blood. The present proposed method for estimating the ketone-value is non-invasive, and its sampling procedure is very easy.