Abstract
Sarcoma was produced by repeatedly injecting 0.4% solution in propylene glycol of m-toluylenediamine subcutaneously into normal rats. Injections were made in doses of 0.5cc at as nearly the same site as possible on the back, and at the rate of once a week for about 8 months, and sarcoma developed in all the 9 rats that survived this period. No notable change in internal organs, no liver cirrhosis in special, was found in these rats.
The possibility of propylene glycol having enhanced the carcinogenic activity of m-toluylenediamine was discussed.
