ON THE ANTI-CANCER ACTION OF QUINOLINE DERIVATIVES

Abstract

A large series of quinoline derivatives were screened as to their anti-cancer action by means of in vitro test, using NF mouse sarcoma, and of in vivo tests, using both ascites and solid forms of Ehrlich mouse carcinoma. As the result of these tests, it was discovered that 4-nitroquinoline-N-oxide, 4-nitro-2-alkylquinoline-N-oxide, and 6-bromo-4-nitroquinoline-N-oxide show a very marked anti-cancer activity.