STUDY OF CARCINOGENIC MECHANISM BASED ON EXPERIMENTS WITH 4-NITROQUINOLINE N-OXIDE
1959 年 50 巻 p. 1-16
詳細
1959 年 50 巻 p. 1-16
The mechanism of carcinogenic action of 4-nitroquinoline N-oxide was analyzed based on the assumption that the substitution reaction with SH compound may be the first reaction which this substance undergoes in vivo. Experimental results indicated that this reaction itself, but not any of the chemical products of the reaction, may be the proximate cause of carcinogenesis, leading to the hypothesis that the energy released by the reaction produces misconstruction of the genetic determinant of the somatic cell (duplicant) by disturbing its normal replication process.
This hypothesis was discussed in relation to the universal proximate mechanism applicable to all the forms of carcinogenesis.
