1. Effects of 110 selected compounds tested against the Friend mouse virus leukemia are reported.
2. Mitomycin C, triethylene melamine, 1, 9-di(methanesulfonoxy)-nonane, and myleran had a destructive effect on the Friend virus leukemia as seen in spleen weight, bioassay and increase in survival time.
3. Urethane,
p-phenylene bis(diethyleneimido phosphate), 6-mercaptopurine, 6-mercaptopurine riboside, thioguanine, 6-(1'-methyl-4'-nitro-5'-imidazolyl)-mercaptopurine, 6-(2, 2-dimethylhydrazino)-purine, purinyl-6-thiocyanate, 9α-fluoro-2α-methylhydrocortisone acetate, estradiol, 3, 3-dimethyl-1-phenyltriazene,
p-(diethyltriazeno) benzenesulfonamide, and netropsin had a markedly inhibitory effect on the Friend virus leukemia.
4. Of the better-known materials HN
2, triethlene thiophosphoramide, purine-6-thioglucoside, thioguanine riboside, 5-fluorouracil, thymine, diethylstilbestrol, azaserine, actinomycin C, 8-nitro-1-methyl-2-quinolone, 4-nitroquinoline-N-oxide, and 6-aminonicotinamide had a moderately inhibitory effect on the Friend virus leukemia, and A-methopterin, 2, 6-diaminopurine, 8-azaguanine, 5-fluorouridine, 5-fluorodeoyuridine, colchicine, cortisone, sarkolysin, chloramphenicol, 6-diazo-5-oxo-
L-norleucine, fumagillin, actinomycin D, podophyllotoxin, ethylenediamine tetraacetic acid, zymosan, potassium arsenite, and H
2O
2 had practically no inhibitoy effect.
抄録全体を表示