SKIN GRAFTS IN DONRYU RATS WITH AND WITHOUT ACQUIRED RESISTANCE TO YOSHIDA SARCOMA AND ASCITES HEPATOMAS

抄録

1) A pedicle cross-skin grafting combined with a short-term parabiosis in normal Donryu rats was 92% successful over 100 days. Similar result was obtained in M520/N(F88) rats, a highly inbred American strain, which served as control. Thus, the genetic homogeneity of the Donryu rats was proved to be very high.
2) The Donryu rats have an extremely high susceptibility to Yoshida sarcoma or ascites hepatomas which originated in these rats. However, they show resistance to tumors after various immunization treatments. All of the cross-skin grafts between these resistance-acquired and normal Donryu rats were rejected by each side of their recipients within 100 days. The fact seemed to be dependent on different compatibility between the donor and host, assuming that histocompatibility system of the resistance-acquired rats has been modified through the acquisition of resistance to the tumors.
3) The Donryu rats, in which the grafts from the parabiosed donors resistant to a tumor were rejected, showed resistance to further challenge of the same tumor. A possible mechanism for this fact was discussed from an immunogenetical viewpoint, and transfer of the resistance during the parabiosis seemed to be a main causal factor.