HEMANGIOMATOUS LESIONS OF MICE TREATED WITH NITROSODIMETHYLAMINE

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The carcinogenic action of nitrosodimethylamine was tested by oral administration of 100ppm in basal diet for 16 to 92 days to DDD mice, and by subcutaneous injection of 0.15mg in 0.2ml of physiological saline into DDD and BALB/c mice once a week for 1 to 35 weeks. These treatments resulted in induction of lung adenomas and carcinomas, and benign and malignant hemangiomas mainly in the liver and soft tissues, and occasionally in the lung, kidney, and spleen, and also of leukemia. The incidence of hemangioendothelial sarcomas in soft tissues, especially pararenal and associated regions, was much higher in the animals receiving the carcinogen by injection. Histogenesis of hemangioendothelial sarcomas of the liver induced by nitrosodimethylamine is described.