EFFECT OF ALLOXAN DIABETES ON HEPATIC CARCINOGENESIS AND CIRRHOSIS IN A×C RATS GIVEN 2-DIACETAMIDOFLUORENE

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Intact and castrated male and female rats with alloxan diabetes were given 0.025% 2-diacetamidofluorene in the diet. Intact male rats given the carcinogen-containing diet developed hepatocellular carcinomas and cirrhosis in high incidence, whereas carcinomas and cirrhosis of the liver were not observed in intact male rats with diabetes. The development of hepatic lesions in intact or castrated females or castrated males was not influenced by the diabetes. It is felt that the animals with diabetes did not develop carcinomas and cirrhosis because of the lack of insulin and its ability to increase protein synthesis in the liver.