抄録
Antitumor and immunosuppressive activities of some lankacidin group (T2636) antibiotics were investigated in vivo and in vitro. Lankacidin-C, Lankacidin-C 8-propionate, and Lankacidin-C 14-propionate, given intraperitoneally, showed inhibitory effects at doses ranging from 25 to 1, 000mg/kg on the growth of the following tumors; leukemia L-1210, lymphosarcoma 6C3HED/OG sensitive to l-asparaginase, and melanoma B-16 in mice. Leukemia L-1210 cells resistant to 6-mercaptopurine or to cytosine arabinoside were also sensitive to the antibiotics. Lankacidin-C 8-propionate and Lankacidin-C 14-propionate inhibited the proliferation of HeLa cells in concentrations of more than 50μg/ml in vitro, whereas Lankacidin-C was not inhibitory.
Lankacidin-C at high doses suppressed the production of antibody against sheep erythrocytes in mice when administered before or after antigenic stimulation. On the contrary, Lankacidin-C 8-propionate slightly suppressed the anibody production only after antigenic stimulation, and Lankacidin-C 14-propionate had no suppressive activity in any conditions.
