PROMOTING EFFECT OF TRISODIUM NITRILOTRIACETATE MONOHYDRATE ON URINARY BLADDER CARCINOGENESIS IN RATS

Shoji FUKUSHIMA; Yasushi KURATA; Seiko TAMANO; Kazuhiko INOUE; Nobuyuki ITO

doi:10.20772/cancersci1985.76.9_823

Shoji FUKUSHIMA, Yasushi KURATA, Seiko TAMANO, Kazuhiko INOUE, Nobuyuki ITO

著者情報

キーワード: N-Butyl-N-(4-hydroxybutyl)nitrosamine, Rat bladder carcinogenesis, Two-stage carcinogenesis, Promotion by Na₃NTA• H₂O

ジャーナルフリー

1985 年 76 巻 9 号 p. 823-827

DOI https://doi.org/10.20772/cancersci1985.76.9_823

詳細

抄録

The promoting effect of trisodium nitrilotriacetate monohydrate (Na₃NTA• H₂O) on two-stage urinary bladder carcinogenesis in F344 rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) at levels of 0.01 and 0.05% was investigated. Administration of 2.0%, Na₃NTA• H₂O significantly increased both the incidence and the number per 10cm of basement membrane of preneoplastic lesions and papillomas of the urinary bladder in rats pretreated with 0.05% BBN. This result shows that Na₃NTA• H₂O has weak promoting activity in urinary bladder carcinogenesis.

責任著者(Corresponding author)

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