抄録
Mice of the CF#1 strain were injected intramuscularly with protein-anabolic steroids (durabolin) of 25mg per kg body weight on the 9th day of gestation. Besides, alloxan of 80mg per kg body weight was given intravenously to the mice on the 10th day of gestation. Blood sugar level was determined on the 12th day of gestation. On the 19th day of gestation, pregnant mice were laparotomized and fetuses were examined. Changes of the maternal body weight during pregnancy and the fetal body weight just after the cesarean section were determined. As control groups, two groups of mice simply given alloxan and durabolin were set up. In the simply alloxanized group, 4.4 percent of the living fetuses were malformed, and in the alloxan-durabolin group, 8.8 percent were malformed. Between these two experimental groups, a significant difference was observed with the probability level of less than 0.05 by the t-test. On the other hand, however, 0.8 percent anomalous fetuses appeared in the durabolin group. Teratogenic capacity of this particular group of mice seems certainly more fragile as compared with the alloxanized as well as the durabolin-alloxan groups. From the findings above-mentioned, the author infers that fetal environment in the diabetic pregnancy may grow worse by the treatment with protein-anabolic steroids from a teratogenic point of view.
