抄録
Some characteristic biological findings have been reported in Down's syndrome. Aging, dental anomalies and high risks for malignant diseases in Down's syndrome are discussed here. Several observations are made on papers by other researchers regarding aging and dental anomalies, and the author's data relevant to further insight into the relationship between Down's syndrome and leukemia are shown. On aging, pathological findings, such as senile dementia, Alzheimer's neurofibrillary degeneration, and granulovacuolar degeneration of nerve cells, the relation between the autosomal aberrations and birthweight, and turn-over rates of cells in Down's syndrome, are discussed. As to dental anomalies, missing teeth, tooth eruption, and abnormalities of tooth shape are discussed. On the relation between Down's syndrome and leukemia, fragility of chromosomes to radiation, measles and chickenpox infections from patients with Down's syndrome are discussed.
