Abstract
Clinical significance of congenital anomaly syndromes is reviewed in relation to teratogen, mutagen and carcinogen. Congenital anomaly syndromes, especially malformations, are important for attracting the eyes of clinicians, particulary pediatricians, so that an effective epidemiological analysis may be conducted to detect teratogens, mutagens or carcinogens. This approach of study is attempting to clinically monitor teratogens, mutagens and carcinogens. Among the various types of congenital anomaly syndrome, the cancer-malformation syndrome (malignancy-congenital anomaly syndrome) has unique significance in clinics. The congenital anomaly syndromes of chromosomal anomalies, immunodeficiencies, inborn errors of metabolism and malformation are high-risk groups for malignancy, including leukemia and malignant lymphoma. The registry of childhood malignancy in Japan organized by the Japan Children's Cancer Association, revealed a statistically significant difference in the pattern of groups of patients with major malformation, minor malformation, both major and minor malformation and with no malformation between leukemia and Wilms' tumor, leukemia and malignant teratoma, and lymphoma and Wilms' tumor.
