official journal of Congeital Anomalies Research Association of Japan
Online ISSN : 2433-1503
Print ISSN : 0037-2285
Volume 15 , Issue 3
Showing 1-19 articles out of 19 articles from the selected issue
  • Type: Cover
    1975 Volume 15 Issue 3 Pages Cover1-
    Published: September 30, 1975
    Released: February 01, 2019
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  • Type: Appendix
    1975 Volume 15 Issue 3 Pages App1-
    Published: September 30, 1975
    Released: February 01, 2019
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  • Type: Index
    1975 Volume 15 Issue 3 Pages Toc1-
    Published: September 30, 1975
    Released: February 01, 2019
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  • Type: Appendix
    1975 Volume 15 Issue 3 Pages App2-
    Published: September 30, 1975
    Released: February 01, 2019
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  • Noboru KOBAYASHI
    Type: Article
    1975 Volume 15 Issue 3 Pages 97-98
    Published: September 30, 1975
    Released: February 01, 2019
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  • Butchi POTTURI Raju, Shamer SlNGH, Ashok SANYAL Kumar
    Type: Article
    1975 Volume 15 Issue 3 Pages 99-106
    Published: September 30, 1975
    Released: February 01, 2019
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    1. Ossification centres of sternum have been studied in 416 rat fetuses (176 in the prenatal and 240 in the perinatal period) after maternal administration of cyclophosphamide during 12th to 14th day of gestation. 2. Ossification defects of sterna were observed in 90 % of the treated fetuses and included missing of 1 or more sternebrae, their irregular shape, rudimentary size, bipartite sternebrae and abnormal intersternebral fusions, the latter showing 15 different patterns. 3. Absence of ossification centres for sternebrae was the most frequent anomaly. 4. Incidence of missing sternebrae was significantly reduced (P < 0.001) when gestation was prolonged (Barrow and Rowland, 1969) and fetuses collected in the perinatal period, indicating recovery from the suppressive effect of the drug on the developing mesenchyme. 5. Treatment on thirteenth day of gestation was found to be most teratogenic for inducing sternal anomalies. 6. Fifth sternebra was most commonly affected.
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  • Kazuyoshi NAKANE, Kiyoshi HOSHlNO, Yoshiro KAMEYAMA
    Type: Article
    1975 Volume 15 Issue 3 Pages 107-116
    Published: September 30, 1975
    Released: February 01, 2019
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    1. The morphological variations of the adult skull of MC mice were examined, in order to know relationships between the spatial deviations of the craniofacial structure and microphthalmia. 2. The variations which were commonly recognized in MC mice and two crossbreeding mice homozygous for the microphthalmic gene of MC mice were fusion of the frontal and parietal bones, posterior shift of the nasal bone, and flexure of the premaxilla and nasal bone. Among these variations, the posterior shift of the nasal bone, which was attributed to smallness of the frontal bone, was a characteristic feature related to microphthalmia.
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  • Haruhiko ANDO, Akira MIZUTANl, Shunji MURACHI
    Type: Article
    1975 Volume 15 Issue 3 Pages 117-126
    Published: September 30, 1975
    Released: February 01, 2019
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    The mortality and cause of 125 deaths among a total of 1,948 discharged patients from the Central Hospital, Aichi Prefectural Colony over a three-year period, January 1, 1971 to December 31, 1973, were investigated through clinical diagnosis and autopsy findings. The International Classification of Diseases Adapted was used to classify the diagnoses and causes of death. The incidence of disease was found to vary with sex among disease classification categories. Relatively higher mortality rates were seen in the categories of nervous system, digestive system, congenital anomalies, and perinatal morbidity. Mortality by sex, however, did not show significant differences within each of these categories. The younger the patient the higher the mortality rate. The major causes of death in the neonates were infections, pulmonary diseases, and CNS diseases.
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  • Takamichi SHIMADA, Akira ENDO, Gen-ichi WATANABE
    Type: Article
    1975 Volume 15 Issue 3 Pages 127-132
    Published: September 30, 1975
    Released: February 01, 2019
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    The percent activity level of heart type subunits of lactate dehydrogenase (H-LDH) in the total LDH complement of embryos from diabetic pregnant mice was significantly lower than in embryos from control mothers, and notably the lowest in malformed embryos from diabetic mothers. The change of H-LDH activity may be related to the production of developmental abnormalities frequently observed in litters born to alloxan-diabetic mothers. A possible etiology of the embryonic deformities is discussed in connection with the activity of lactate dehydrogenase isoenzymes.
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  • Masaru OHTSU, Takashi SUGISAKI, Takashi SAKAGUCHI
    Type: Article
    1975 Volume 15 Issue 3 Pages 133-137
    Published: September 30, 1975
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    The structure of the auto-staining apparatus for teratological specimens newly developed by us was explained, and the most appropriate procedure of skeletal staining with alizarin red S for teratological investigations with this apparatus was described. This auto-staining apparatus enables us to stain the skeleton of about 200 specimens of mouse or rat fetuses, about 50 specimens of the reared young of rats, or about 70 specimens of the reared young of mice, at the same time in a day, and thus the labor and time required for the skeletal staining in the course of teratological investigations can be saved.
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  • Yasuo NAKAGOME
    Type: Article
    1975 Volume 15 Issue 3 Pages 139-149
    Published: September 30, 1975
    Released: February 01, 2019
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    Twelve major chromosome aberration syndromes had been established prior to the "ban-ding breakthrough." Eight of them involved autosomes and four of them sex chromosomes. The former included 21 trisomy (Down's syndrome), 18 trisomy, 13 trisomy, 5p- (cat cry), 4p-, 18q-, 18p- and 13q- syndromes. The latter group consisted of Turner's, Klinefelter's super female and YY syndromes (Table 2). The use of new banding techniques has made it possible to identify any changes of a karyotype in great detail. The abnormal karyotypes so far reported in the literature were summarized in Tables 3 and 4. Among them, the following appeared to be acceptable as cytogenetic entities, each with a characteristic pattern of congenital abnormalities: 8 trisomy, 9p trisomy, 9 trisomy, 10 trisomy, 10p trisomy, 10q distal trisomy, 4p trisomy, 4q distal trisomy, 14q proximal trisomy, 21 (partial) monosomy and 22 (partial) monosomy. Their clinical features were briefly reviewed.
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  • Makoto HIGURASHI
    Type: Article
    1975 Volume 15 Issue 3 Pages 151-155
    Published: September 30, 1975
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    Some characteristic biological findings have been reported in Down's syndrome. Aging, dental anomalies and high risks for malignant diseases in Down's syndrome are discussed here. Several observations are made on papers by other researchers regarding aging and dental anomalies, and the author's data relevant to further insight into the relationship between Down's syndrome and leukemia are shown. On aging, pathological findings, such as senile dementia, Alzheimer's neurofibrillary degeneration, and granulovacuolar degeneration of nerve cells, the relation between the autosomal aberrations and birthweight, and turn-over rates of cells in Down's syndrome, are discussed. As to dental anomalies, missing teeth, tooth eruption, and abnormalities of tooth shape are discussed. On the relation between Down's syndrome and leukemia, fragility of chromosomes to radiation, measles and chickenpox infections from patients with Down's syndrome are discussed.
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  • Yoshiyuki SUZUKI
    Type: Article
    1975 Volume 15 Issue 3 Pages 157-162
    Published: September 30, 1975
    Released: February 01, 2019
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    Inborn disorders of glycosphingolipids, mucopolysaccharides and glycoproteins were reviewed, and the concept of mucolipidosis was briefly discussed. It was emphasized that the complex polysaccharide metabolism should be studied comprehensively in order to understand the chemical pathology in relation to the clinical aspects of these disorders.
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  • Noboru KOBAYASHI
    Type: Article
    1975 Volume 15 Issue 3 Pages 163-168
    Published: September 30, 1975
    Released: February 01, 2019
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    Clinical significance of congenital anomaly syndromes is reviewed in relation to teratogen, mutagen and carcinogen. Congenital anomaly syndromes, especially malformations, are important for attracting the eyes of clinicians, particulary pediatricians, so that an effective epidemiological analysis may be conducted to detect teratogens, mutagens or carcinogens. This approach of study is attempting to clinically monitor teratogens, mutagens and carcinogens. Among the various types of congenital anomaly syndrome, the cancer-malformation syndrome (malignancy-congenital anomaly syndrome) has unique significance in clinics. The congenital anomaly syndromes of chromosomal anomalies, immunodeficiencies, inborn errors of metabolism and malformation are high-risk groups for malignancy, including leukemia and malignant lymphoma. The registry of childhood malignancy in Japan organized by the Japan Children's Cancer Association, revealed a statistically significant difference in the pattern of groups of patients with major malformation, minor malformation, both major and minor malformation and with no malformation between leukemia and Wilms' tumor, leukemia and malignant teratoma, and lymphoma and Wilms' tumor.
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  • Type: Appendix
    1975 Volume 15 Issue 3 Pages 169-171
    Published: September 30, 1975
    Released: February 01, 2019
    JOURNAL FREE ACCESS
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  • Type: Appendix
    1975 Volume 15 Issue 3 Pages 172-174
    Published: September 30, 1975
    Released: February 01, 2019
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  • Type: Appendix
    1975 Volume 15 Issue 3 Pages 175-
    Published: September 30, 1975
    Released: February 01, 2019
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  • Type: Cover
    1975 Volume 15 Issue 3 Pages Cover2-
    Published: September 30, 1975
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    Download PDF (33K)
  • Type: Cover
    1975 Volume 15 Issue 3 Pages Cover3-
    Published: September 30, 1975
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    Download PDF (33K)
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