サリチル酸剤(アセチル・サリチル酸およびフエニール・サリチル酸)投与による奇形の実験的発生

抄録

This paper refers to characteristics of the experimental malformations produced by acetyl salicylate (aspirin) and phenylsalicylate (salol). Female primiparous rats (Wistar-Funahashi strain) weighing 130-200g were fed with Funahashi solid diet. Aspirin of doses of 660 mg, 330mg and 165mg/kg was orally administered to the pregnant rats on each day from the 7th to 12th, 9th to 11th, 9th to 14th and 12th to 14th day of gestation. Salol was administered on each day from the 7th to 9th and 7th to 12th day of gestation. For the dosage factor 400mg, 300mg 200mg and 100mg/kg we e used. The above chemicals was given as a suspension of 0.5% C.M.C. immediately before administrations. Parallel to the dosage or the stage of administration frequency of macerated embryos or fetuses and malformations of the fetuses were increased in number. All fetuses were malformed in the group which was treated with the dose of 660mg/kg on each day from the 9th to 11th and 9th to 14th day of gestation. Malformations manifested were as follows: exencephaly, encephalocele, encephalomyeloschisis, myeloschisis, micro-or anophthalmos, naked eye, cleft palate, harelip and upper cheilognathoschisis. Malformations of the viscera were hydronephrosis and hydrourether. There were rare cases of unilateral agensis and hypoplasia. Some fetuses showed only one malformation, however, many fetuses had more than two malformations as stated above. Such changes, especially malformations of the ribs, vertebrae, and of the upper extremities. Such malformations of the upper extremities were aplasia or hypoplasia of the ulna or radius and in some cases such malformations with the upper extremities were associated with oligodactylism.