Abstract
We chemically synthesized several (+)-catechin glycosides which included (+)-catechin 3-O-β-D-glucopyranoside, -3-O-α-D-mannopyranoside, -3-O-β-D-xylopyranoside, -3-β-β- D -galactopyranoside, and -3-O-β-maltoside. The yields of the glycosides were improved by using silver perchlorate and silver trifluoromethanesulfonate as condensing agents. The use of these condensing agents shortened the reaction time also.
The inhibitory activities of these glycosides were examined against several enzymes including tyrosinase, xanthine oxidase, β-galactosidase, hyaluronidase and peroxidase. The glycosides highly inhibited tyrosinase activity and inhibited f3-galactosidase activity to a certain extent. On the other hand, inhibitory effects of the glycosides on hyaluronidase and peroxidase were rather lower than the lead compound, (+)-catechin.
