It was commonly believed that there was high incidence of mixed infection with gram-negative bacilli in the patients whose general condition were so poor and postoperative infections were prolonged, and the management of those patients were extremely complicated. In this study, the authors performed basic and clinical experiment on gentamicin, to which gram-negative bacilli showed higher sensitivity as compared with other antibiotics, and it was obtained interesting results as follows :
1. Mean MIC of gentamicin for 104 strains of gram-negative bacilli was 0.84mcg/ml and that of Pseudomonas aeruginosa was 3.4 mcg/ml.
2. The blood level of gentamicin was 3.2mcg/ml at 30 minutes after the intramuscular administration of 40 mg of gentamicin, then it dropped quickly. But the blood level was 0.1-0.5mcg/ml at 12 hours after the administration.
3. The urine excretion of gentamicin was reached to 36.5% in the male of 60 kg, 33.4% in the male of 75 kg, and 10.0% in the male of 90 kg at 6 hours after the intramuscular administration of 40 mg of gentamicin.
4. In 13 clinical cases, the effective rates were evaluated to be 85% and there was not found any remarkable associated effect, especially concerning liver and renal function. Additionally, the authors discussed briefly on indication of gentamicin in the treatment of gram-negative bacilli and Pseudomonas aeruginosa infection in our Department.
