STUDIES ON ANTI-TUMOR AGENTS. V
Studies on the Absorption, Distribution and Excretion of TC-17 in Experimental Animals
1970 年 18 巻 4 号 p. 465-468
詳細
1970 年 18 巻 4 号 p. 465-468
The physiological disposition of TC-17 in tumor-bearing mice, rabbits and normal rats was investigated.
When TC-17 was injected parenterally, various tissue levels increased rapidly and were retained in high levels in the body for 10 days or more. Peak values in various tissue levels in rats receiving TC-17 intraperitoneally in a single does of 100 mg/kg were found at 5 or 10 days after the injection and the drug was concentrated temporarily in lung and kidney. Serum half-life was about 14 days.
Serum half-life in tumor-bearing rabbits receiving 50 mg/kg of the drug intravenously was about 4 days.
Urinary excretion of the drug was almost none in rats and rabbits, and its biliary excretion was a little.
Repeated intraperitoneal injections on tumor-bearing mice showed accumulation of the drug in liver, kidney and testis.
At rabbit serum levels of 100 to 500, μg/ml, about 50% of TC-17 bound with the serum proteins, and TC-17 serum protein complex occurred the ionic dissociation in electrophoreetic process.
