1, 2-Bis [5 (or 6) -methoxy-2-benzimidazolyl] 1, 2-ethanediolの抗ポリオウイルス作用

抄録

The mechanism of the antiviral action of 1, 2-bis [5 (or 6) -methoxy-2-benzimidazolyl] 1, 2-ethanediol (BMBID) was investigated using the poliovirus-HeLa S₈ cell system. The compound has no direct inactivating effect on virus infectivity, nor does it inhibit adsorption of virus to cells. Under conditions of a single cycle of multiplication, BMBID at 35.4 mcg/ml (0.1 mM) concentration inhibits virus reproduction when added at the time of virus inoculation, but it was ineffective when the host cells were treated for 24 hours before infection.
The BMBID-resistant poliovirus was not obtained from serial passages in BMDID-containing medium, and also BMBID inhibits the multiplication both of 2- (α-hydroxybenzyl) benzimidazole (HBB) -resistant and guanidine-resistant poliovirus.