異なつた作用を有する2種の合成ペニシリン (ampicillin, dicloxacillin) の併用療法について
1971 年 19 巻 2 号 p. 129-132
詳細
1971 年 19 巻 2 号 p. 129-132
Ten patients ranging in ages of 5 to 60 with various infections such as pyelocystitis, acute bronchitis, cholecystitis, cholelithiasis, pneumonia, meningitis (diabetes insipidus), pericarditis and myeloma were treated with Cilleral (ampicillin) 1, 000 mg daily in 4 divided doses orally or intramuscularly in 2 divided doses and Clocil (dicloxacillin) 500 mg daily in 4 divided doses orally. The doses were reduced to one-half for children. The duration of administration ranged from 7 to 15 days. The efficacy of treatment was judged by fever, subjective symptoms and laboratory findings.
This combination therapy was markedly effective in 3 cases, effective in 4 and not effective in 3. In the effective cases the efficacy was observed in several days with fever and other symptoms sub- siding.
There were no side effects. When considering the problem of infection by resistant staphylococci the combination of penicillin for resistant staphylococci with a broad spectrum penicillin has a significant meaning.
