口腔外科領域でのClocil (Dicloxacillin) の使用経験

抄録

A new semi-synthetic, penicillinase resistant penicillin, dicloxacillin was orally administered for many types of oral infections and prophylactically for the postoperatives, during five months in 1968.
Cases of oral pyogenic infections were 37 and those of postoperatives were 7. To these 44 cases, dicloxacillin capsules were given 500-1, 000 mg per day, every 6 hours for 1-16 days. Its clinical effectiveness was evaluated chiefly from the improvement of signs and from the frequency of untoward reactions. The former was found in 80% of total cases, and the latter in none. Precise evaluation would be difficult from these results, as the bacteriological examinations had not been done in this trial.
The greater parts of causative microorganisms in oral infections were gram positive cocci, in which there were many, β-lactamase producing organism. Dicloxacillin was resistant to penicillinase, and its oral administration gave the high level of blood concentration and few allergic side effects. It will be, therefore, advisable to treat oral infections by dicloxacillin.