SulfamethoxazoleとTrimethoprimの合剤の作用についての知見
1973 年 21 巻 2 号 p. 104-109
詳細
1973 年 21 巻 2 号 p. 104-109
Combined activities of trimethoprim (TMP) and sulfamethoxazole (SMX) on clinically isolated strains of Staphylococcus aureus, Escherichia coli and Shigella flexineri were studied by the agar dilution and crossed paper strip methods. The combined drug was shown to have a synergistic action against 48 strains of Staphylococcus aureus tested, without regard to their sensitivities to sulfonamide and to tetracyclin. The synergism of combined drug was also observed in 4 strains of sulfonamide-sensitive Escherichia coli. On the other hand, no synergistic action to 24 strains of sulfonamide resistant Escherichia coli and 14 strains of Shigella flexineri was detected by the methods mentioned above, regardless of existance of R factors in these strains.
