Sulfamethoxazole-Trimethoprim合剤による尿路感染症の治験

抄録

Sulfamethoxazole (SMX) -trimethoprim (TMP) combination product was given in a trial of 22 outpatients comprising 13 females with acute cystitis, 4 females with other urinary tract infections and 5 males with prostatitis. The drug was administered for a period of 5 days and the response was followed every 5 days.
In acute cystitis, the response was classified as markedly effective in 1, effective in 10, fair in 1 and undetermined in 1. In other varieties of female urinary tract infections, the drug therapy was judged as effective in 3 and fair in 1. For the treatment of prostatitis, the combination product was markedly effective in 1, effective in 2, fair in 1 and undetermined in 1. The overall effective rate was 77%. Two patients with allergic diathesis developed untoward reactions and the drug administration was therefore discontinued.
Side effects, mainly those of gastro-intestinal disturbance, were observed in 6 patients. Although the memler of treated cases is small, the effect of this combination preparation in prostatitis was impressive.