抄録
Sulfamethoxazole-trimethoprim combination (abbrv : ST) showed satisfactory antibacterial activity against Gram negative enteric bacteria and some strains belonging to Pseudomonacea. Potentiating property of this combination drug was found especially against moderately or highly resistant organisms.
When employed for the treatment of complicated urinary tract infections, ST was shown to be useful in long-term management of chronic infections, though recurrence rate was not appreciably low. Efficacy of ST was almost comparable to gentamicin or carbenicillin in short-term response. An episode of gastro-intestinal discomfort with vomitting and another incidence of skin eruption were the untowards reactions among the 16 adults and 19 children, the latter patients showed positive skin reaction on patch test.
