尿路感染症におけるSulfamethoxazole-Trimethoprim合剤の基礎的, 臨床的検討

抄録

Experimental and clinical investigations of a new antimicrobial agent, sulfamethoxazole (SMX) -trimethoprim (TMP) combination product, were carried out. The peak serum levels were recorded 4 hours after oral administration, whereas urinary concentrations reached at peak at 4 to 6 hours post-dose. Thirty-five patients with urinary tract infections were treated by SMX-TMP combination product. The effective rate in acute inflammation was 100%, that in chronic infection 61.5%, that in uncomplicated infection 82.3% and that in complicated infection 55.5%. Four patients complained of gastro-intestinal disturbance.