抄録
We presented some fundamental and clinical studies on the combined drug of sulfamethoxazole and trimethoprim. MIC was measured with total of 45 strains ; Escherichia coli NIHJ, Staphylococcus aureus 209P and others.
Escherichia coli, Staphylococcus and Klebsiella revealed sensitivity against trimethoprim, while Proteus showed relative sensitivity.
However, Pseudomonas and Alcaligenes were resistant to trimethoprim as well as sulfamethoxazole. No synergistic action was observed between trimethoprim and sulfamethoxazole.
Clinical studies showed that urinary tract infection caused by Escherichia coli and Staphylococcus were satisfactorily controlled with the drug.
No side effect on subjective symptom, liver and kidney function, except a case with gastric disorder, was marked with the administration of this combined drug.
