抄録
The comparison was made on the antibacterial activity of SF-837 and other macrolide antibiotics against 96 strains of Staphylococcus aureus isolated clinically, as well as the cross resistance was investigated.
The MIC of SF-837 was distributed among 0.8-3.1 mcg/ml, and the peak was recognized at 1.5 mcg/ml. Fourteen strains showed an MIC even at >100 mcg/ml. The MIC of SF-837 was almost the same as that of JM (josamycin) or LM (leucomycin).
The cross resistance was investigated between SF-837 and LM, EM (erythromycin), MJ and Acetyl-SPM (acetyl-spiramycin) respectively. The results obtained demonstrated that a correlation exists between SF-837 and each other drug. The resistant strains of >100 mcg/ml were noticed at the ratio of 14-15% with each antibiotic.
