It is important that the host-parasite-drug relationship is taken into consideration in the case of chemotherapy. The immunosuppressive effect of CP and RFP was reported recently. Therefore, the influence of antibiotics on infection, tuberculin reaction to BCG immunization and the lysosomal enzyme activity of macrophages and WBCs was investigated. The results are as follows :
1. The pre-treatment with CP, KM, TC and PCG in mice is brought about easy infection to St. aureus.
2. The treatment with RFP, CP and TC in guinea pigs suppresses the tuberculin reaction to BCG immunization.
3. RFP and CP in mice and CP, RFP, TC and SM in guinea pigs obviously suppress the enzyme activity of macrophages.
4. The treatment with CP, RFP, TC and SM in guinea pigs suppresses the peroxidase activity of WBCs.
5. The above results should be taken into consideration in the case of the treatment of large dosis and the long term treatment and opportunistic infections.
