抄録
Laboratory and clinical studies were carried out on pivampicillin and the following results were obtained.
1) Serum antibacterial titers against standard strains of Staphylococcus aureus, gram-negative rods (E. coli, Klebsiella pneumoniae, Proteus vulgaris, and Pseudomonas aeruginosa) were not much different between ampicillin and pivampicillin.
2) Concentrations of pivampicillin in blood and organs during oral administration in rats were twice as large or greater than those of ampicillin.
3) Excretion into the bile from removed rat liver under perfusion was significantly greater for pivampicillin than ampicillin. With a change in excretion amounts along with the time course, results similar to a change of concentration in the blood were obtained.
4) This antibiotic was clinically used in 18 cases of infections with less than moderate severity in the field of internal medicine, mainly consisting of respiratory infections. Excellent effects were seen in 2, good effects in 13, no effect in 1 and unknown in 2. As for side effects, skin allergies were seen in 2 and gastrointestinal symptoms in 3.
