産婦人科領域におけるCefatrizineの基礎的, 臨床的検討

抄録

1. Minimal inhibitory concentration of cefatrizine (CFT) against the strains clinically isolated from the patients suffering from various infections in the obstetric and gynecological fields was studied in comparison with cephalexin (CEX) CFT's MIC against Staphylococcus aureus, Escherichia coli and Klebsiella was one tube stronger and its MIC against Proteus mirabilis was 2 to 3 tubes stronger when compared with CEX. MIC against Proteus vulgaris and Pseudomonas aeruginosa was more than 100 μg/ml in CFT and CEX.
2. Blood level in umbilical code and amniotic fluid level when 500 mg of CFT was given orally to mothers was studied. The serum level of umbilical code was not less than one-third when compared with mothers serum level. Therefore, CFT seems to pass well into umbilical code. On the other hand, the level of CFT in amniotic fluid was as low as that of other antibiotics.
3. Eighteen patients with infectious diseases in the obstetric and gynecological field were orally given CFT at daily doses of 1 to 2 g for 4 to 10 days. The result obtained was marked effective in 4 patients, effective in 11 and ineffective in 3.
4. Three out of 18 patients complained of loss of appetite, but it was slight and did not obstruct the continuation of dosing. BUN, GOT, GPT, Al-phosphatase and WBC were checked, and no abnormal findings were noted.