In this paper, the biliary excretion of SBPC and CEZ was clinically studied in 15 patients with obstructive jaundice after Percutaneous Transhepatic Cholangio-Drainage (PTC-D).
The sertm and bile levels were determined at daily intervals after one-hour intravenous infusion of the antibiotics.
The excretion rate was expressed as percent of the rate of peak levels of serum and those of bile.
The biliary excretion of the antibiotics showed a certain change at time intervals which was not correlated to kinds and dose of the antibiotics administered. Starting at day 4 after PTC-D, there was a period of about 3 weeks during which biliary excretion rate was decreased remarkably. These results would be valuable for the chemotherapy of patients with the biliary tract obstruction.
