Aminoglycoside系抗生物質 : KW-1062に関する薬理学的研究 第2報 生体内動態

抄録

Distribution, fate and excretion of KW-1062, a new aminoglycoside antibiotic, were investigated in rats and mice. When rats were intravenously and intramuscularly injected KW-1062 at a dose of 5 mg/kg, biological half lives were 8. 23 and 37. 26 min, respectively. The biological half life of KW-1062 in the injected site of muscle was 20. 56 min. KW-1062 was well absorbed from muscle and rapidly eliminated from blood. The serum level and organ levels were proportionally increased with the doses applied, and all organ levels were lower than the serum level. KW-1062 was hardly absorbed from intestine. The total amount excreted in 24 hr urine of the rat was 70% of the injected amount. The cord blood levels were 36. 79 to 66. 55% of maternal serum levels in the pregnant rats. The fetal organ levels were very low. Approximately 10. 57 and 19. 16% of KW-1062 were bound to human plasma and to bovine serum, respectively.