KW-1062の吸収・体内分布・排泄・代謝

抄録

Absorption, distribution, excretion and metabolism of KW-1062, a new aminoglycoside antibiotic, were studied in the test animals after subcutaneous or intramuscular administratration of 10 mg/kg.
KW-1062 was extremely well absorbed when given in mice, rats and dogs. The peak of plasma concentration of KW-1062 ranged from about 15 to 20 μg/ml at 15 or 30 minutes in animals. No plasma activity was noticed at 3 or 4 hours after administration. KW-1062 was distributed into various organs and the concentration in kidney remained very high for a long period of time. The other tissue concentrations of KW-1062 in animals were lower than the concentration of plasma. Most of the administered KW-1062 was excreted mainly through the urinary tract. The 24 hour urinary recovery rate was approximately 80% in rats and dogs. The biliary excretion rate in rats after intramuscular administration of 50 mg/kg was very small. No active metabolites were found in urine of rats and dogs, but only KW-1062 itself was excreted. The significant difference was not observed in the pharmacological results between KW-1062 and GM.