小児科領域におけるTicarcillinの基礎的ならびに臨床的検討

抄録

The authors have carried out the laboratory and clinical studies of ticarcillin.
The results were as follows;
The sensitivity was measured by the cup plate dilution method with 31 strains of Ps. aeruginosa, 14 strains of E. coli, 15 strains of Klebsiella pneumoniae and 32 strains of Staph. aureus. The growth of 48.2% of Ps. aeruginosa was inhibited in concentration of less than 25 μg/ml. The antimicrobial activity of ticarcillin was 2 times the activity of carbenicillin. The growth of 57. 1% of E. coli and of 40. 6% of Staph. aureus was inhibited in concentration of less than 12. 5 μg/ml and 3. 13 μg/ml, respectively. But Klebsiella pneumoniae was not sensitive to ticarcillin.
Ticarcillin was given a single intravenous dose of 50 mg per kg b. w. to two children. The maximum blood level was reached at one hour after drip infusion (for 1 hour). And these levels were 90 μg/ml and 138 μg/ml, respectively.
And the levels at 4 hours after injection were 2. 7 μg/ml and 5. 2 μg/ml, respectively. The excretion rate of ticarcillin in urine after injection was 83. 2-90. 7% up to 6 hours of period.
Ticarcillin was clinically applied to 2 cases of pneumonia and 2 cases of urinary tract infection. Good response was obtained in 3 cases.
Eosinophilia occurred in one patient.