Ticarcillin (TIPC) was administered to 22 cases of urinary tract infection, septicemia and its suspected, and acute pneumonia which were hospitalized in the Department of Pediatrics, Kurume University School of Medicine. Clinical effects and side effects were investigated with the treatment, as well as sensitivity of isolates to the drug was compared with CBPC, SBPC and ABPC.
The antibiotic was one shot administered intravenously at a dose of 28-369 mg/kg (189 mg/kg on the average). As the result, global effects were excellent in 4 cases, good in 9 cases, none in 5 cases and unknown in 4 cases, effective ratio being 72.2%.
As to the drug sensitivity of E. coli, antibacterial activity was the strongest for CBPC, followed by TIPC at inoculum size of 108/ml, while it was the strongest for TIPC at 106/ml. TIPC showed the strongest activity against Kl. pneumoniae and Pr. mirabilis. Against Ps. aeruginosa, TIPC exhibited 50-≥100 μg/ml at 108/ml, and some strains showed less than 1/2 MIC compared with SBPC and CBPC, as well as MIC of TIPC ranged 3. 12-100 μg/ml at 106/ml, proving thus this antibiotic is the most superior among 4 drugs.
As for the side effect of one shot intravenous administration, 7 cases complained of pain at blood vessel, and 1 case transient eruption. As to the laboratory finding, LDH value worsened in 1 case of which value had been higher before the drug administration, and BUN value rose slightly in 1 case. Other abnormalities would have been rather due to the underlying disease.
