1. Minimum inhibitory concentration of Sisomicin was determined on 111 strains isolated from urinary tract infections by plate dilution method.
In 108 inoculum density, all strains of E. coli were inhibited at 6.25 μg/ml or less and most strains of Pseudomonas aeruginosa at 12.5 μg/ml or less. Eleven out of 19 strains of Serratia were resistant to 100 μg/ml of Sisomicin. Antibacterial activity of Sisomicin against clinical isolates is equal to or stronger than that of Gentamicin.
2. In one patient with normal renal function, a peak blood level of 12.0 μg/ml was obtained one hour after intramuscular administration of 50 mg. Urinary recovery rate was 81.8% within 6 hours.
3. Twenty cases with complicated urinary tract infections were treated with 100 mg/day. “Excellent” and “good” results were achieved in 8 out of 19 patients. One patient did not complete trial.
4. Slight elevations of GOT and GPT in 2 and of Al. P-ase in 1 patient were observed.
