Pharmacokinetic and clinical studies of biapenem in the field of obstetrics and gynecology

Abstract

The pharmacokinetic and clinical studies of biapenem (BIPM), a new 4-methylc arbapenem antibiotic possessing a stability for human renal dehydropeputidase-I were carried out.
1. The concentration of BIPM was examined in serum, internal genital organs and retroperitoneal fluid after intravenous administration of 0.3 g dose. The peak serum concentrations in the cubital vein and uterine artery were 15.8 and 15.0 ugfrnl, respectively, while the genital tissue concentration was 5.3 μg/g. The peak level of retroperitoneal fluid was 8.2 μg/ml.
2. BIPM was administered to 11 patients. Clinical response was good in 9 cases andunknown in 2 cases. Principal causative organisms were Eikenella corrodens, Clostridium sp. and Fusobacterium sp. and the bacteriological response was evaluated as eradicated in 2 strain and as replaced 1 strain. In one patient, the side effects of lip numbness and vomiting and the elevation of GOT, GPT, γ-GTP value in laboratory findings were observed.