Fundamental and clinical studies on biapenem in the field of obstetrics and gynecology

Abstract

Fundamental and clinical studies on biapenem (BIPM), a newly developed parenteral carbapenem antibiotic, were performed and the results were summarized as follow.
1. The concentrations of BIPM in plasma and female genital organs after a single d. i. administration of 300 mg for 60 minutes were examined. The drug transferred into tissues of female genital organs and remained a level of 0.6μg/g even at 176 min.
2. BIPM was given to 6 patients with gynecological infections. Clinical results were excellent in 1, good in 4, and poor in 1.
3. No side effects or abnornal laboratory findings were observed.