マウスの繁殖能力に及ぼす原子炉(JRR-1)照射の影響 I. 成熟雄に照射した場合の体重および主な内分泌器官の重量変化について

田中 亮一; 柏原 孝夫

doi:10.2508/chikusan.42.96

Effects of the JRR-1 irradiation on reproductive function of the mouse

I. Effects of the irradiation on body weight and internal gland weight of adult male mouse

Ryoichi TANAKA, Takao KASHIWABARA

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JOURNAL FREE ACCESS

1971 Volume 42 Issue 2 Pages 96-102

DOI https://doi.org/10.2508/chikusan.42.96

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Published: February 25, 1971 Received: September 14, 1970 Available on J-STAGE: March 10, 2008 Accepted: - Advance online publication: - Revised: -
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Date of correction: March 10, 2008 Reason for correction: - Correction: PDF FILE Details: -

Date of correction: March 10, 2008 Reason for correction: - Correction: PDF FILE Details: -

Date of correction: March 10, 2008 Reason for correction: - Correction: ABSTRACT Details: Wrong : Body weight and weight of testis, hypophysis and adrenal of adult male mouse were investigated under the condition of pile irradiation of 40kW thermal neutron target skin distance of 20cm (No. 7 hole, JRR-1, Japan Research Reactor No. 1 of Japan Atomic Energy Research Institute), and three exposure times of 1 (1H), 2 (2H) and 3.5 (3.5H) hours respectively. The effects of long term raising of the mouse after pile irradiation were presented as the variation
of body weight and internal gland weight.
The results obtained were as follows:
1. When we compared the body weight curve (see Fig. 2) of 3.5H group with that of 1H group and control, large difference was not observed, contrary to expectation, but 2H group was diminished than the other groups.
2. In 3.5H group, two mice which were irradiated in the exposed position F died within 30 days after irradiation and from 30th day to 100th day after irradiation no mortality was observed. In 2H group, two mice which were irradiated in the exposed position F were sacrificed at 16th day after irradiation for the aim of histological observation, therefore, if they were not sacrificed, they could survive several days and would have died within 30 days after irradiation as was recognized in Fig. 1. The other two mice which were irradiated in exposed position FM were died between 30th day and 100th day after irradiation. Accordingly, the 2H group was more sensitive than the 3.5H group against lethal effects of irradiation. It was considered that the unexpected results mentioned above were due to different season of the raising after irradiation, that is, season of the raising after irradiation of the 3.5H group were more favourable than that of the 2H group.
3. The time of exposure of total body JRR-1 irradiation required to kill 50 per cent of the adult male mice within 30 days after irradiation was about 2 hours at the exposed position F in the No. 7 hole. The dosage of 2 hours of exposure was presumed to be 7.2-36.0×10¹⁰n/cm²
Nutron flux density and 400-800 R γ-ray from Kakei's data.
4. The weight of testis decreased in long term raising after irradiation (see Table 2). The hypophysis showed no change in weight but the adrenal weighed more than the control.
Right : Body weight and weight of testis, hypophysis and adrenal of adult male mouse were investigated under the condition of pile irradiation of 40kW thermal neutron target skin distance of 20cm (No. 7 hole, JRR-1, Japan Research Reactor No. 1 of Japan Atomic Energy Research Institute), and three exposure times of 1 (1H), 2 (2H) and 3.5 (3.5H) hours respectively. The effects of long term raising of the mouse after pile irradiation were presented as the variation of body weight and internal gland weight.
The results obtained were as follows:
1. When we compared the body weight curve (see Fig. 2) of 3.5H group with that of 1H group and control, large difference was not observed, contrary to expectation, but 2H group was diminished than the other groups.
2. In 3.5H group, two mice which were irradiated in the exposed position F died within 30 days after irradiation and from 30th day to 100th day after irradiation no mortality was observed. In 2H group, two mice which were irradiated in the exposed position F were sacrificed at 16th day after irradiation for the aim of histological observation, therefore, if they were not sacrificed, they could survive several days and would have died within 30 days after irradiation as was recognized in Fig. 1. The other two mice which were irradiated in exposed position FM were died between 30th day and 100th day after irradiation. Accordingly, the 2H group was more sensitive than the 3.5H group against lethal effects of irradiation. It was considered that the unexpected results mentioned above were due to different season of the raising after irradiation, that is, season of the raising after irradiation of the 3.5H group were more favourable than that of the 2H group.
3. The time of exposure of total body JRR-1 irradiation required to kill 50 per cent of the adult male mice within 30 days after irradiation was about 2 hours at the exposed position F in the No. 7 hole. The dosage of 2 hours of exposure was presumed to be 7.2-36.0×10¹⁰n/cm² Nutron flux density and 400-800 R γ-ray from Kakei's data.
4. The weight of testis decreased in long term raising after irradiation (see Table 2). The hypophysis showed no change in weight but the adrenal weighed more than the control.

Date of correction: March 10, 2008 Reason for correction: - Correction: DTPUB Details: Right : 19710225

Date of correction: March 10, 2008 Reason for correction: - Correction: PDF FILE Details: -

Abstract

Body weight and weight of testis, hypophysis and adrenal of adult male mouse were investigated under the condition of pile irradiation of 40kW thermal neutron target skin distance of 20cm (No. 7 hole, JRR-1, Japan Research Reactor No. 1 of Japan Atomic Energy Research Institute), and three exposure times of 1 (1H), 2 (2H) and 3.5 (3.5H) hours respectively. The effects of long term raising of the mouse after pile irradiation were presented as the variation of body weight and internal gland weight.
The results obtained were as follows:
1. When we compared the body weight curve (see Fig. 2) of 3.5H group with that of 1H group and control, large difference was not observed, contrary to expectation, but 2H group was diminished than the other groups.
2. In 3.5H group, two mice which were irradiated in the exposed position F died within 30 days after irradiation and from 30th day to 100th day after irradiation no mortality was observed. In 2H group, two mice which were irradiated in the exposed position F were sacrificed at 16th day after irradiation for the aim of histological observation, therefore, if they were not sacrificed, they could survive several days and would have died within 30 days after irradiation as was recognized in Fig. 1. The other two mice which were irradiated in exposed position FM were died between 30th day and 100th day after irradiation. Accordingly, the 2H group was more sensitive than the 3.5H group against lethal effects of irradiation. It was considered that the unexpected results mentioned above were due to different season of the raising after irradiation, that is, season of the raising after irradiation of the 3.5H group were more favourable than that of the 2H group.
3. The time of exposure of total body JRR-1 irradiation required to kill 50 per cent of the adult male mice within 30 days after irradiation was about 2 hours at the exposed position F in the No. 7 hole. The dosage of 2 hours of exposure was presumed to be 7.2-36.0×10¹⁰n/cm² Nutron flux density and 400-800 R γ-ray from Kakei's data.
4. The weight of testis decreased in long term raising after irradiation (see Table 2). The hypophysis showed no change in weight but the adrenal weighed more than the control.

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