The Effect of Atropine on Pancreatic Responses to Intravenous CCK-8 and Intraduodenal Soybean Extract in Sheep

Abstract

The effects of intravenous infusion of atropine on pancreatic exocrine responses to exogenous CCK-8 and to endogenous CCK-PZ released by intraduodenal administration of soybean extract were examined in sheep. Atropine did not inhibit the response of exocrine pancreas to CCK-8 injected intravenously. Intraduodenal administration of soybean extract increased juice flow (2.87-fold), protein output (3.71-fold) and amylase output (3.56-fold), which were significantly inhibited by atropine infusion showing a small increase of juice flow but no increases of protein and amylase outputs. These results indicate that the cholinergic mechanism is not involved in the action of CCK-8 on pancreatic acinar cell, but the release of CCK-PZ from intestinal mucosal cell is considerably mediated by the cholinergic mechanism in sheep.